43,147 research outputs found

    Local Spin Susceptibility of the S=1/2 Kagome Lattice in ZnCu3(OD)6Cl2

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    We report single-crystal 2-D NMR investigation of the nearly ideal spin S=1/2 kagome lattice ZnCu3(OD)6Cl2. We successfully identify 2-D NMR signals originating from the nearest-neighbors of Cu2+ defects occupying Zn sites. From the 2-D Knight shift measurements, we demonstrate that weakly interacting Cu2+ spins at these defects cause the large Curie-Weiss enhancement toward T=0 commonly observed in the bulk susceptibility data. We estimate the intrinsic spin susceptibility of the kagome planes by subtracting defect contributions, and explore several scenarios.Comment: 4 figures; published in PR-B Rapid Communication

    The effect of pre-processing and grain structure on the bio-corrosion and fatigue resistance of magnesium alloy AZ31

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    Magnesium alloys are broadly used for structural applications in the aerospace and automotive industries as well as in consumer electronics. While a high specific strength is the forte of magnesium alloys, one serious limitation for Mg alloys is their corrosion performance. Unlike aluminium, it does not form a stable passive film to provide long-term protection from further corrosion. The poor corrosion resistance of magnesium and magnesium alloys is regarded as a major drawback, and significant effort has been focused on improving this.[1-3] However, the high reactivity of magnesium alloys in corrosive media can be used to advantage in biomedical applications, particularly in temporary implants where the capacity of a material for bio-degradation is one of the most sought after properties. Indeed, permanent implant materials, such as stainless steel, titanium alloys or Nitinol (55Ni-45Ti), are the only choices currently available for hard tissue implantation. They can cause permanent physical irritation, long-term endothelial dysfunction and chronic inflammatory local reaction. Sometimes a second operation is needed for the implant to be removed. Given the ability of the human body to gradually recover and regenerate damaged tissue, the ideal solution would thus be a degradable implant, which would offer a physiologically less invasive repair and temporary support during tissue recovery. After fulfilling its function, this implant would be obliterated, being absorbed by the body. This philosophy of implant surgery would also be of particular interest for endovascular stent

    IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

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    Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD. In AD, the accumulation of β-amyloid (Aβ) in the brain perturbs physiological functions of the brain, including synaptic and neuronal dysfunction, microglial activation, and neuronal loss. Serum levels of soluble ST2 (sST2), a decoy receptor for interleukin (IL)-33, increase in patients with mild cognitive impairment, suggesting that impaired IL-33/ST2 signaling may contribute to the pathogenesis of AD. Therefore, we investigated the potential therapeutic role of IL-33 in AD, using transgenic mouse models. Here we report that IL-33 administration reverses synaptic plasticity impairment and memory deficits in APP/PS1 mice. IL-33 administration reduces soluble Aβ levels and amyloid plaque deposition by promoting the recruitment and Aβ phagocytic activity of microglia; this is mediated by ST2/p38 signaling activation. Furthermore, IL-33 injection modulates the innate immune response by polarizing microglia/macrophages toward an antiinflammatory phenotype and reducing the expression of proinflammatory genes, including IL-1β, IL-6, and NLRP3, in the cortices of APP/PS1 mice. Collectively, our results demonstrate a potential therapeutic role for IL-33 in AD

    Enforcement against contract violation in Chinese construction projects: impacts of trust and perceived intentionality

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    Violations happen frequently in construction projects due to opportunistic intentions and/or the lack of awareness of obligations and/or honest attempts to react to unforeseen circumstances. Dealing with contract violations plays an important role in managing projects. The aim of the research is to investigate the impact of trust, analyzed in terms of the goodwill-based and competence-based trust, on both contract and social enforcement after a contract violation. A questionnaire survey, partially based on semi-structured interviews, was used for data collection. All the data is from the Chinese construction industry since it provides a fertile context to explore the research questions. The results show that: 1) reputation is used as social enforcement in practice and the severity of it is reflected by the scope of the disclosure, 2) the two dimensions of trust have opposite influences on the severity of contract and social enforcement via different mediating effects of perceived intentionality. Specifically, goodwill-based trust reduces the severity of enforcement via decreasing perceived intentionality, while competence-based trust increases the severity of enforcement by increasing perceived intentionality. A comprehensive and nuanced understanding for managing contract violation is generated in this research, which will help project managers to manage the contract violation and the interfirm relationships more effectively

    On Mitigation of Side-Channel Attacks in 3D ICs: Decorrelating Thermal Patterns from Power and Activity

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    Various side-channel attacks (SCAs) on ICs have been successfully demonstrated and also mitigated to some degree. In the context of 3D ICs, however, prior art has mainly focused on efficient implementations of classical SCA countermeasures. That is, SCAs tailored for up-and-coming 3D ICs have been overlooked so far. In this paper, we conduct such a novel study and focus on one of the most accessible and critical side channels: thermal leakage of activity and power patterns. We address the thermal leakage in 3D ICs early on during floorplanning, along with tailored extensions for power and thermal management. Our key idea is to carefully exploit the specifics of material and structural properties in 3D ICs, thereby decorrelating the thermal behaviour from underlying power and activity patterns. Most importantly, we discuss powerful SCAs and demonstrate how our open-source tool helps to mitigate them.Comment: Published in Proc. Design Automation Conference, 201

    Optimal nonlocal multipartite entanglement concentration based on projection measurements

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    We propose an optimal nonlocal entanglement concentration protocol (ECP) for multi-photon systems in a partially entangled pure state, resorting to the projection measurement on an additional photon. One party in quantum communication first performs a parity-check measurement on her photon in an N-photon system and an additional photon, and then she projects the additional photon into an orthogonal Hilbert space for dividing the original NN-photon systems into two groups. In the first group, the N parties will obtain a subset of NN-photon systems in a maximally entangled state. In the second group, they will obtain some less-entangled N-photon systems which are the resource for the entanglement concentration in the next round. By iterating the entanglement concentration process several times, the present ECP has the maximal success probability which is just equivalent to the entanglement of the partially entangled state. That is, this ECP is an optimal one.Comment: 5 pages, 4 figure
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